Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding
hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid …

Fracture healing and distraction osteogenesis have important applications in orthopedic,
maxillofacial, and periodontal treatment. In this review, the cellular and molecular …

Using a moderate‐sized cohort selected with extreme BMD (n= 344; absolute value BMD,
1.5–4.0), significant association of several members of the Wnt signaling pathway with bone …

Osteoporosis is characterized by low bone mineral density and structural deterioration of
bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone …

Numerous physiological processes of mammals, including bone metabolism, are regulated
by the circadian clock system, which consists of a central regulator, the suprachiasmatic …

Bone is a highly vascularized organ, providing structural support to the body, and its
development, regeneration, and remodeling depend on the microvascular homeostasis …

There are both theoretical and empirical underpinnings that provide evidence that the
musculoskeletal system develops, functions, and ages as a whole. Thus, the risk of …

Background Current genome-wide association studies (GWAS) are normally implemented in
a univariate framework and analyze different phenotypes in isolation. This univariate …

Osteoporotic fractures show reduced callus formation and delayed bone healing. Cellular
sources of fracture healing are mesenchymal stem cells (MSC) that differentiate into …

Although bone mineral density (BMD) is a complex trait that is influenced by both genetic
and environmental factors, heritability studies in twins and families have shown that genetic …