Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading
deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite …

Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …

B-cell lymphoma is a group of hematological malignancies with high clinical and biological
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …

Background Atezolizumab is an inhibitor of PD-L1, which can lead to enhanced anticancer T-
cell activity. We aimed to evaluate the safety, pharmacokinetics, and activity of atezolizumab …

Purpose The occurrence pattern of immune-related adverse events (irAEs) induced by
immune checkpoint inhibitor (ICI) in cancer treatment remains unclear. Materials and …

Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node
Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol - PMC …

Cancer immunotherapy has reshaped the landscape of cancer treatment. However, its
efficacy is still limited by tumor immunosuppression associated with the excessive …

Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly
aggressive ovarian malignancy. In almost all cases, it is associated with somatic and often …