Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D Xiao, L Lu, B Liang, Z Xiong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Synthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment
A library of novel bis-Schiff base derivatives based on thiobarbituric acid has been
effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti …
effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti …
Antioxidant Activity, Molecular Docking and Quantum Studies of New Bis‐Schiff Bases Based on Benzyl Phenyl Ketone Moiety
In the current research work novel bis‐Schiff base products of benzyl phenyl ketone nucleus
were synthesized via two step reactions in excellent yields. Using FTIR, EI‐MS and 1H‐NMR …
were synthesized via two step reactions in excellent yields. Using FTIR, EI‐MS and 1H‐NMR …
Multifaceted bioactivity of thiosemicarbazide derivatives: Synthesis, characterization, and DFT investigations on inhibition of α-amylase, hydroxyl radical scavenging …
In this study, eight bioactive thiosemicarbazide derivatives (3a-h) were synthesized and
characterized through 1 HNMR, 13 CNMR and Mass spectroscopic techniques. Finally, their …
characterized through 1 HNMR, 13 CNMR and Mass spectroscopic techniques. Finally, their …
Technology Innovation-institutional Quality on Environmental Pollution Nexus From E-7 Nations: Evidence From Panel Ardl Cointegration Approach
This groundbreaking study looked at the issue of pollution of the environment in the E7
countries from 2002 and 2022. We implemented ARDL to investigate how GDP, institutional …
countries from 2002 and 2022. We implemented ARDL to investigate how GDP, institutional …
Novel Benzimidazole Derivatives as Effective Inhibitors of Prolyl Oligopeptidase: Synthesis, in Vitro and in Silico Analysis
Background: This research aims to discover novel derivatives having potential therapeutic
applications in treating conditions related to prolyl oligopeptidase (POP) dysfunction …
applications in treating conditions related to prolyl oligopeptidase (POP) dysfunction …
Polyhydroquinoline Derivatives for Diabetic Management: Synthesis, in Vitro and in Silico Approaches
F Talab, Zainab, A Alam, M Ali… - Future Medicinal …, 2023 - Taylor & Francis
Background: Medication used to treat Type 2 diabetes by decreasing the absorption of
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
Exploring the anti-diabetic activity of benzimidazole containing Schiff base derivatives: In vitro α-amylase, α-glucosidase inhibitions and in silico studies
The current study explores the anti-diabetic potential of some Schiff bases containing
benzimidazole scaffold. These derivative were synthesized by refluxing sodium metabisulfite …
benzimidazole scaffold. These derivative were synthesized by refluxing sodium metabisulfite …
Synthesis of novel thiazole derivatives containing 3-methylthiophene carbaldehyde as potent anti α-glucosidase agents: In vitro evaluation, molecular docking …
Thiazole derivatives bearing thiophene carbaldehyde have been successfully prepared by
refluxing 3-methylthiophene carbaldehyde with thiosemicarbazide in absolute ethanol …
refluxing 3-methylthiophene carbaldehyde with thiosemicarbazide in absolute ethanol …
Synthesis, anticancer, α-glucosidase inhibition, molecular docking and dynamics studies of hydrazone-Schiff bases bearing polyhydroquinoline scaffold: In vitro and in …
A series of hydrazone-Schiff base derivatives of polyhydroquinoline (PHQ) nucleus have
been synthesized, structurally deduced by NMR (13 C-and 1 H-) and HR-ESI-MS …
been synthesized, structurally deduced by NMR (13 C-and 1 H-) and HR-ESI-MS …