Current and future directions of deep brain stimulation for neurological and psychiatric disorders: JNSPG 75th Anniversary Invited Review Article

DJ Lee, CS Lozano, RF Dallapiazza… - Journal of neurosurgery, 2019 - thejns.org
Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it
has primarily been used to treat movement disorders such as Parkinson's disease, essential …

State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities

N Engels-Domínguez, EA Koops, PC Prokopiou… - Neuroscience & …, 2023 - Elsevier
Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting

P Teli, V Kale, A Vaidya - Cell and Tissue Research, 2023 - Springer
Neurodegenerative diseases (NDs) are characterized by uncontrolled loss of neuronal cells
leading to a progressive deterioration of brain functions. The transition rate of numerous …

A transatlantic viewpoint on the role of pallidal stimulation for Parkinson's disease

A Boogers, A Fasano - Movement Disorders, 2024 - Wiley Online Library
For many neurologists, crossing borders during training is part of the trajectory to becoming
a movement disorders specialist and offers novel insights. In this viewpoint, we discuss how …

Pathological correlates of cognitive decline in Parkinson's disease: from molecules to neural networks

NI Novikov, ES Brazhnik, VF Kitchigina - Biochemistry (Moscow), 2023 - Springer
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by the death
of dopaminergic neurons in the substantia nigra and appearance of protein aggregates …

A novel dopamine D3R agonist SK609 with norepinephrine transporter inhibition promotes improvement in cognitive task performance in rodent and non-human …

JS Schneider, CA Marshall, L Keibel, NW Snyder… - Experimental …, 2021 - Elsevier
Mild cognitive impairment is present in a number of neurodegenerative disorders including
Parkinson's disease (PD). Mild cognitive impairment in PD (PD-MCI) often manifests as …

Deep brain stimulation in Alzheimer's disease: Targeting the nucleus basalis of Meynert

Y Chen, K Shu, H Kang - Journal of Alzheimer's Disease, 2021 - content.iospress.com
Alzheimer's disease (AD) is becoming a prevalent disease in the elderly population. Past
decades have witnessed the development of drug therapies with varying targets. However …

Neuroimaging evaluation of deep brain stimulation in the treatment of representative neurodegenerative and neuropsychiatric disorders

S Peng, V Dhawan, D Eidelberg, Y Ma - Bioelectronic Medicine, 2021 - Springer
Brain stimulation technology has become a viable modality of reversible interventions in the
effective treatment of many neurological and psychiatric disorders. It is aimed to restore …

The role of the nucleus basalis of Meynert in neuromodulation therapy: a systematic review from the perspective of neural network oscillations

L Jiao, H Kang, Y Geng, X Liu, M Wang… - Frontiers in Aging …, 2024 - frontiersin.org
As a crucial component of the cerebral cholinergic system and the Papez circuit in the basal
forebrain, dysfunction of the nucleus basalis of Meynert (NBM) is associated with various …

Case Report: Deep Brain Stimulation of the Nucleus Basalis of Meynert for Advanced Alzheimer's Disease

W Zhang, W Liu, B Patel, Y Chen, K Wang… - Frontiers in human …, 2021 - frontiersin.org
Patients with advanced Alzheimer's disease (AD) experience cognitive impairment and
physical disabilities in daily life. Currently, there are no treatments available to slow down …