Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion
to prevent negative consequences for the tissue or the organism. Dysfunctional apoptosis is …

Hepatocellular carcinoma (HCC) is one of the most common cancers and has a high
mortality rate in less developed countries, especially in China. Galangin (GA), one of the …

Regulated cell death is essential in development and cellular homeostasis. Multi-protein
platforms, including the Death-Inducing Signaling Complex (DISC), co-ordinate cell fate via …

TRAIL and FasL are potent inducers of apoptosis but can also promote inflammation through
assembly of cytoplasmic caspase-8/FADD/RIPK1 (FADDosome) complexes, wherein …

Cellular Signal Processing offers a unifying view of cell signaling based on the concept that
protein interactions act as sophisticated data processing networks that govern intracellular …

Pinostrobin (PN) is a naturally occurring dietary bioflavonoid, found in various medicinal
herbs/plants. Though anti-cancer potential of many such similar constituents has been …

Autophagosomal membranes are emerging as platforms for various cell survival and death
signaling networks beyond autophagy. While autophagy-dependent cell death has been …

Simple Summary p53 is best known for its tumour suppressive functions mediated through
regulation of an extensive-gene regulatory network. Here we review progress in our …

Abstract The Inhibitor of Apoptosis proteins (IAPs) are a family of proteins that are mainly
known for their anti-apoptotic activity and ability to directly bind and inhibit caspases. Recent …

The death-inducing signaling complex (DISC) is a fundamental multiprotein complex, which
triggers the extrinsic apoptosis pathway through stimulation by death ligands. DISC consists …