Most of the genetic information has been lost or transferred to the nucleus during the
evolution of mitochondria. Nevertheless, mitochondria have retained their own genome that …

Cervical cancer develops through persistent infection with high-risk human papilloma virus
(hrHPV) and is a leading cause of death among women worldwide and in the United States …

Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

Mitochondria serves a primary role in energy maintenance but also function to govern levels
of mitochondria-derived reactive oxygen species (mROS). ROS have long been established …

Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Lung cancer is the leading cause of cancer-related mortality. While the majority of lung
cancers are associated with tobacco smoke, approximately 10–15% of US lung cancers …

Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the
homeostasis of a healthy network of functioning mitochondria and prevents excessive …

Despite advances in clinical therapy, metastasis remains the leading cause of death in
breast cancer patients. Mutations in mitochondrial DNA, including those affecting complex I …

Although Bcl-2 family proteins were originally identified as key regulators of apoptosis, an
impressive body of evidence has shown that pro-survival members of the Bcl-2 family …