Our desire to understand how the individual molecules that make up cells organize, interact,
and communicate to form living systems has led to the burgeoning field of chemical biology …

Retinal cell survival requires an equilibrium between oxygen, reactive oxygen species, and
antioxidant molecules that counteract oxidative stress damage. Oxidative stress alters cell …

Iron is an essential component in many biological processes in the human body. It is critical
for the visual phototransduction cascade in the retina. However, excess iron can be toxic …

Abstract Significance: Anthracyclines (doxorubicin, daunorubicin, or epirubicin) rank among
the most effective anticancer drugs, but their clinical usefulness is hampered by the risk of …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Iron has emerged as a significant cause of neurotoxicity in several neurodegenerative
conditions, including Alzheimer's disease (AD), Parkinson's disease (PD), sporadic …

The significance of oxidative stress in the development of chronic neurodegenerative
diseases of the retina has become increasingly apparent in recent years. Reactive oxygen …

Increased levels of reactive oxygen species (ROS) have been associated with numerous
pathophysiological conditions including cancer and inflammation and the ROS stimulus …

The retinal pigment epithelium (RPE) performs a range of necessary functions within the
neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and …

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with
elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress …