AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate
most fast excitatory neurotransmission. The component subunits determine the functional …

Neural circuits must maintain stable function in the face of many plastic challenges,
including changes in synapse number and strength, during learning and development …

The study of synaptic plasticity and specifically LTP and LTD is one of the most active areas
of research in neuroscience. In the last 25 years we have come a long way in our …

Central sensitization represents an enhancement in the function of neurons and circuits in
nociceptive pathways caused by increases in membrane excitability and synaptic efficacy as …

Long-term depression (LTD) in the CNS has been the subject of intense investigation as a
process that may be involved in learning and memory and in various pathological …

AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Amyloid-β oligomers may cause cognitive deficits in Alzheimer's disease by impairing
neuronal NMDA-type glutamate receptors, whose function is regulated by the receptor …

Abstract N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP)
and long-term depression (LTD) of signal transmission form neural circuits and thus are …

Accumulating data, including those from large genetic association studies, indicate that
alterations in glutamatergic synapse structure and function represent a common underlying …