The potential for positron emission tomography (PET) to detect neuroinflammation in vivo
has sparked a remarkable interest in various disciplines of neuroscience. Early PET …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

The purpose of this study was to investigate the link between mutant huntingtin (Htt) and
neuronal damage in relation to mitochondria in Huntington's disease (HD). In an earlier …

The basal ganglia are a highly interconnected set of subcortical nuclei and major atrophy in
one or more regions may have major effects on other regions of the brain. Therefore, the …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Levodopa-induced dyskinesias (LIDs) are the most common and disabling adverse motor
effect of therapy in Parkinson's disease (PD) patients. In this study, we investigated …

Microglia are the main immune cells in the brain, playing a role in both physiological and
pathological conditions. Microglial involvement in neurodegenerative diseases is well …

Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

In recent years, several therapeutic drugs have been rationally designed and synthesized
based on the novel knowledge gained from investigating the actions of biologically active …