Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …

The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

The presence of mitochondria and related organelles in every studied eukaryote supports
the view that mitochondria are essential cellular components. Here, we report the genome …

The lysosome is a degradative organelle, and its fusion with other organelles is strictly
regulated. In contrast to fusion with the late endosome, the mechanisms underlying …

Autophagy is the engulfment of cytosol and organelles by double-membrane vesicles
termed autophagosomes. Autophagosome formation is known to require …

Few components of the mitochondrial fission machinery are known, even though
mitochondrial fission is a complex process of vital importance for cell growth and survival …

Drp1 (dynamin-related protein 1) is recruited to both mitochondrial and peroxisomal
membranes to execute fission. Fis1 and Mff are Drp1 receptor/effector proteins of …

Summary Tail-anchored (TA) proteins, defined by the presence of a single C-terminal
transmembrane domain (TMD), play critical roles throughout the secretory pathway and in …

Membrane proteins are inserted into the endoplasmic reticulum (ER) by two highly
conserved parallel pathways. The well-studied co-translational pathway uses signal …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …