Titanium is the second most abundant transition metal and is already a key player in
important industrial processes (eg polyethylene). Titanium is an attractive metal to use for …

1. INTRODUCTION The chemistry of three-membered ring heterocycles has played a
dominant role in the history of organic synthesis. 1 Countless classic and modern protocols …

The mechanisms of most organic reactions are considered to proceed by two-electron
transfer pathways, even though both biology and radical chemistry rely extensively on one …

Selective hydrogenation of epoxides would be a direct and powerful approach for alcohol
synthesis, but it has proven to be elusive. Here, electrochemically epoxide hydrogenation …

New catalytic strategies that leverage single-electron redox events have provided chemists
with useful tools for solving synthetic problems. In this context, Ti offers opportunities that are …

The first enantioselective cross-electrophile coupling of aryl bromides with meso-epoxides to
form trans-β-arylcycloalkanols is presented. The reaction is catalyzed by a combination of …

Epoxides are versatile intermediates in organic synthesis, but have rarely been employed in
cross-coupling reactions. We report that bipyridine-ligated nickel can mediate the addition of …

Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Ring-opening of epoxides furnishing either linear or branched products belongs to the group
of classic transformations in organic synthesis. However, the regioselective cross …

Organic radicals are generally short-lived intermediates with exceptionally high reactivity.
Strategically, achieving synthetically useful transformations mediated by organic radicals …