Dexamethasone (DEX) has been widely used to treat a variety of diseases, including
autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19 …

Autotaxin (ATX) is a secreted enzyme that produces lysophosphatidate (LPA), which signals
through six G-protein coupled receptors, promoting tumor growth, metastasis, and survival …

Autotaxin (ATX) is a secreted enzyme that produces extracellular lysophosphatidate in
physiological wound healing. ATX is overexpressed in many cancers to promote growth …

Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong
to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum …

Autotaxin (ATX; ENPP2) is a secreted lysophospholipase D catalyzing the extracellular
production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and …

There is an under-recognized role of the aryl hydrocarbon receptor (AhR) in co-ordinating
the entry and pathophysiology of the severe acute respiratory syndrome-coronavirus-2 …

After a decade of intense preclinical investigations, the first in-class autotaxin inhibitor,
GLPG1690, has entered Phase III clinical trials for idiopathic pulmonary fibrosis. In the …

Background HDL has been proposed to possess anti-inflammatory properties; however, the
detail mechanisms have not been fully elucidated. Methods We investigated the roles of …

Autotaxin (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to produce
lysophosphatidate (LPA), which signals through six G-protein coupled receptors (GPCRs) …

Besides serving as a structural membrane component and intermediate of the glycerolipid
metabolism, lysophosphatidic acid (LPA) has a prominent role as a signaling molecule …