Chronic pain patients frequently develop and suffer from mental comorbidities such as
depressive mood, impaired cognition, and other significant constraints of daily life, which …

Pain is an essential protective mechanism meant to prevent tissue damages in organisms.
On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve …

Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous
system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

Current treatments for chronic pain rely largely on opioids despite their substantial side
effects and risk of addiction. Genetic studies have identified in humans key targets pivotal to …

The discovery of robust antidepressant effects of ketamine in refractory patients has led to
increasing focus on agents targeting glutamatergic signaling as potential novel …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

Chronic pain is a frequent, distressing and poorly understood health problem. Plasticity of
synaptic transmission in the nociceptive pathways after inflammation or injury is assumed to …

Metabotropic glutamate receptors (mGluR or mGlu) are G-protein coupled receptors
activated by the binding of glutamate, the main classical neurotransmitter of the nervous …

In humans, affective consequences of neuropathic pain, ranging from depression to anxiety
and anhedonia, severely impair quality of life and are a major disease burden, often …