Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder characterized by left
ventricular hypertrophy, hyperdynamic contraction, and impaired relaxation of the heart …

Ca2+ regulation of contraction in vertebrate striated muscle is exerted primarily through
effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural …

Do biological motors move with regular steps? To address this question, we constructed
instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular …

A new in vitro assay using a feedback enhanced laser trap system allows direct
measurement of force and displacement that results from the interaction of a single myosin …

Mavacamten, formerly known as MYK-461 is a recently discovered novel small-molecule
modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of …

THE genomes of all eukaryotes contain tracts of DNA in which a single base or a small
number of bases is repeated. Expansions of such tracts have been associated with several …

With the advent of technologies to obtain the complete sequence of the human genome in a
cost-effective manner, this decade and those to come will see an exponential increase in our …

Molecular motors are protein machines whose directed movement along cytoskeletal
filaments is driven by ATP hydrolysis. Eukaryotic cells contain motors that help to transport …

MCAK belongs to the Kin I subfamily of kinesin-related proteins, a unique group of motor
proteins that are not motile but instead destabilize microtubules. We show that MCAK is an …

The myosin head consists of a globular catalytic domain that binds actin and hydrolyzes ATP
and a neck domain that consists of essential and regulatory light chains bound to a long …