The cone-shaped capsid enclosing the viral RNA genome and the replication machinery is
the hallmark of mature human immunodeficiency virus 1 (HIV-1). Over the past decade, our …

The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment
the core is released into the cytoplasm, it interacts with a range of cellular factors that …

Reverse transcription, an essential event in the HIV-1 life cycle, requires deoxynucleotide
triphosphates (dNTPs) to fuel DNA synthesis, thus requiring penetration of dNTPs into the …

In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the
capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry …

Transcriptionally latent forms of replication-competent proviruses, present primarily in a
small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection …

The mature HIV-1 capsid is stabilized by host and viral determinants. The capsid protein CA
binds to the cellular metabolites inositol hexakisphosphate (IP6) and its precursor inositol (1 …

HIV-1 infection requires passage of the viral core through the nuclear pore of the cell, a
process that depends on functions of the viral capsid. Recent studies have shown that HIV-1 …

Retroviral reverse transcription starts within the capsid and uncoating and reverse
transcription are mutually dependent. There is still debate regarding the timing and cellular …

The human immunodeficiency virus type 1 (HIV-1) can infect fully differentiated, nondividing
cells by interacting with the host nuclear pore complex. The host nuclear pore protein …