Beyond its remarkable genome editing ability, the CRISPR/Cas9 effector has also been
utilized in biosensing applications. The recent discovery of the collateral RNA cleavage …

Infectious diseases are one of the most intimidating threats to human race, responsible for
an immense burden of disabilities and deaths. Rapid diagnosis and treatment of infectious …

Rapid detection of nucleic acids is integral to applications in clinical diagnostics and
biotechnology. We have recently established a CRISPR-based diagnostic platform that …

A rapid and sensitive isothermal method is crucial for point-of-care (POC) nucleic acid
testing. Recently, RNA-guided CRISPR/Cas12a proteins were discovered to exhibit target …

Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods,
soil or water can dramatically improve clinical outcomes and reduce the socioeconomic …

Ideal methods for detecting pathogens should be sensitive, specific, rapid, cost-effective and
instrument-free. Conventional nucleic acid pathogen detection strategies, mostly PCR …

Viruses are ubiquitous in the environment. While many impart no deleterious effects on their
hosts, several are major pathogens. This risk of pathogenicity, alongside the fact that many …

Abstract Rapid, sensitive, point-of-care diagnostics are critical for managing infectious
diseases. Here we adapt the CRISPR-based SHERLOCK method to develop a rapid …

CRISPR (Clustered regularly interspaced short palindromic repeats)‐based diagnostic
technologies have emerged as a promising alternative to accelerate delivery of SARS‐CoV …

Infectious meningitis can be caused by viral, bacterial or fungal pathogens. Despite widely
available treatments, many types of infectious meningitis are still associated with significant …