Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that
of humans, providing a unique opportunity to study disease biology and evaluate novel …

Clinical care of osteosarcoma (OSA) in companion dogs has been relatively static during the
past 20 years. The disease of OSA can be described as one of “life and limb.” The limb pain …

Despite the advancements in treatments for other cancers, the outcomes for osteosarcoma
(OSA) patients have not improved in the past forty years, especially in metastatic patients …

Background: Osteosarcoma (OS) represents the most common primary bone tumor in
humans and in companion dogs, being practically phenotypically identical. There is a need …

Osteosarcoma (OSA) is the most common pediatric malignant bone tumor. Although surgery
together with neoadjuvant/adjuvant chemotherapy has improved survival for localized OSA …

Recent studies have highlighted a key role played by the sympathetic nervous system (SNS)
and adrenergic stress in mediating immune suppression associated with chronic …

Focal radiation therapy (RT) has attracted considerable attention as a combinatorial partner
for immunotherapy (IT), largely reflecting a well-defined, predictable safety profile and at …

In veterinary oncology, canine melanoma is still a fatal disease for which innovative and
long-lasting curative treatments are urgently required. Considering the similarities between …

Purpose Osteosarcoma (OS) is the most frequently diagnosed bone cancer in children with
little improvement in overall survival in the past decades. The high surface expression of …

Advancements in molecular imaging and drug targeting have created a renaissance in the
development of radiopharmaceuticals for therapy and theranostics. While some …