Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

The mechanistic target of rapamycin complex 1 (mTORC1) is an essential regulator of cell
growth and metabolism through the modulation of protein and lipid synthesis, lysosome …

The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …

PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …

Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling hub integrates multiple
environmental cues to modulate cell growth and metabolism. Over the past decade …

The class I phosphoinositide 3-kinase (PI3K)–mechanistic target of rapamycin (mTOR)
complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation …

Despite development of novel agents targeting oncogenic pathways, matching targeted
therapies to the genetic status of individual tumors is proving to be a daunting task for …

The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) serves
as a key conduit between growth signals and the metabolic processes underlying cell …