Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma
membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors …

The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid,
adrenal, reproductive, and growth functions. The gland responds to complex central and …

BACKGROUND: Six known steps are required for the circulating thyroid hormone (TH) to
exert its action on target tissues. For three of these steps, human mutations and distinct …

At least six major steps are required for secreted thyroid hormone (TH) to exert its action on
target tissues. Mutations interfering with three of these steps have been so far identified. The …

Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism
and account for less than 2% of all pituitary adenomas. In the last years, the diagnosis has …

Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of
hyperthyroidism and they are characterized by elevated serum levels of free thyroid …

Pituitary adenomas (PAs) can be classified as non-secreting adenomas, somatotroph
adenomas, corticotroph adenomas, lactotroph adenomas, and thyrotroph adenomas …

The molecular genetic basis of thyroid carcinogenesis is not well understood. Most of the
existing models of thyroid cancer only rarely show metastases, and this has limited progress …

For a long time it has been known that both hypo-and hyperthyroidism are associated with
an increased risk of morbidity and mortality. In recent years, it has also become clear that …

BACKGROUND: Thyroid hormone receptors (TRs) are ligand-dependent transcription
factors that mediate the actions of the thyroid hormone (T3) in development, growth, and …