Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …

Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …

It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

In contrast to the multiple disease-modifying therapies that are available for relapsing–
remitting multiple sclerosis (MS), the therapeutic options for progressive MS (PMS) are …

Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In
the aged brain, senescent cell identities and the mechanisms by which they exert adverse …

Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a
central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia …

Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Senescent cells are generally characterized by permanent cell cycle arrest, metabolic
alteration and activation, and apoptotic resistance in multiple organs due to various …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …