Polyphenolic compounds are present in different parts of plants, including the root, stem,
bark, leaves, seeds and fruits. They have been reported for their various biological functions …

Insulin-like Growth Factor (IGF)/IGF-1 Receptor (IGF-1R) signaling is known to regulate stem
cell pluripotency and differentiation to trigger cell proliferation, organ development, and …

Aims Insulin like growth factor binding protein 7 (IGFBP7) is a marker of senescence
secretome and a novel biomarker in patients with heart failure (HF). We evaluated the …

Glioblastoma multiforme (GBM) is the most common primary brain malignancy and is often
resistant to conventional treatments due to its extensive cellular heterogeneity. Thus, the …

Background High-grade serous ovarian cancer (HGSOC) has poor survival rates due to a
combination of diagnosis at advanced stage and disease recurrence as a result of …

Cell–cell communication events (CEs) are mediated by multiple ligand–receptor (LR) pairs.
Usually only a particular subset of CEs directly works for a specific downstream response in …

Heart failure (HF) is a rising global cardiovascular epidemic driven by aging and chronic
inflammation. As elderly populations continue to increase, precision treatments for age …

Osteosarcoma affects both adolescents and adults, and some improvement in the survival
rate for affected patients has been reached in the last decade. Still, non-specificity and …

Prostate Cancer (PCa) is a leading cause of cancer-related morbidity and mortality in men.
Therefore, novel mechanistically-driven approaches are needed for PCa management …

Obesity is a pandemic of increasing worldwide prevalence. There is evidence of an
association between obesity and the risk of prostate cancer from observational studies, and …