Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells …
R Holtappels, S Becker, S Hamdan, K Freitag… - PLoS …, 2023 - journals.plos.org
Cytomegaloviruses (CMVs) are host species-specific in their replication. It is a hallmark of all
CMVs that productive primary infection is controlled by concerted innate and adaptive …
CMVs that productive primary infection is controlled by concerted innate and adaptive …
Non-redundant and redundant roles of cytomegalovirus gH/gL complexes in host organ entry and intra-tissue spread
NAW Lemmermann, A Krmpotic, J Podlech… - PLoS …, 2015 - journals.plos.org
Herpesviruses form different gH/gL virion envelope glycoprotein complexes that serve as
entry complexes for mediating viral cell-type tropism in vitro; their roles in vivo, however …
entry complexes for mediating viral cell-type tropism in vitro; their roles in vivo, however …
The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription
B Chan, V Gonçalves Magalhães… - PLoS …, 2017 - journals.plos.org
The type I interferon (IFN) response is imperative for the establishment of the early antiviral
immune response. Here we report the identification of the first type I IFN antagonist encoded …
immune response. Here we report the identification of the first type I IFN antagonist encoded …
Evaluating human T-cell therapy of cytomegalovirus organ disease in HLA-transgenic mice
S Thomas, S Klobuch, J Podlech, B Plachter… - PLoS …, 2015 - journals.plos.org
Reactivation of human cytomegalovirus (HCMV) can cause severe disease in recipients of
hematopoietic stem cell transplantation. Although preclinical research in murine models as …
hematopoietic stem cell transplantation. Although preclinical research in murine models as …
Cytomegalovirus inhibitors of programmed cell death restrict antigen cross-presentation in the priming of antiviral CD8 T cells
S Ebert, V Böhm, JK Büttner, W Brune… - Plos …, 2024 - journals.plos.org
CD8 T cells are the predominant effector cells of adaptive immunity in preventing
cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection …
cytomegalovirus (CMV) multiple-organ disease caused by cytopathogenic tissue infection …
Insufficient antigen presentation due to viral immune evasion explains lethal cytomegalovirus organ disease after allogeneic hematopoietic cell transplantation
R Holtappels, SI Schader, O Oettel… - Frontiers in cellular …, 2020 - frontiersin.org
Reactivation of latent cytomegalovirus (CMV) poses a clinical problem in transiently
immunocompromised recipients of hematopoietic cell (HC) transplantation (HCT) by viral …
immunocompromised recipients of hematopoietic cell (HC) transplantation (HCT) by viral …
Modulation of cytomegalovirus immune evasion identifies direct antigen presentation as the predominant mode of CD8 T-cell priming during immune reconstitution …
R Holtappels, JK Büttner, K Freitag… - Frontiers in …, 2024 - frontiersin.org
Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of
hematopoietic cell transplantation (HCT) in the period between a therapeutic …
hematopoietic cell transplantation (HCT) in the period between a therapeutic …
Memory CD8 T cells protect against cytomegalovirus disease by formation of nodular inflammatory foci preventing intra-tissue virus spread
R Holtappels, J Podlech, K Freitag, NA Lemmermann… - Viruses, 2022 - mdpi.com
Cytomegaloviruses (CMVs) are controlled by innate and adaptive immune responses in an
immunocompetent host while causing multiple organ diseases in an immunocompromised …
immunocompetent host while causing multiple organ diseases in an immunocompromised …
Reconstitution of CD8 T cells protective against cytomegalovirus in a mouse model of hematopoietic cell transplantation: dynamics and inessentiality of epitope …
R Holtappels, NAW Lemmermann, J Podlech… - Frontiers in …, 2016 - frontiersin.org
Successful reconstitution of cytomegalovirus (CMV)-specific CD8+ T cells by hematopoietic
cell transplantation (HCT) gives a favorable prognosis for the control of CMV reactivation …
cell transplantation (HCT) gives a favorable prognosis for the control of CMV reactivation …
Positive role of the MHC class-I antigen presentation regulator m04/gp34 of murine cytomegalovirus in antiviral protection by CD8 T cells
S Becker, A Fink, J Podlech, I Giese… - Frontiers in Cellular …, 2020 - frontiersin.org
Murine cytomegalovirus (mCMV) codes for MHC class-I trafficking modulators m04/gp34,
m06/gp48, and m152/gp40. By interacting with the MHC class-Iα chain, these proteins …
m06/gp48, and m152/gp40. By interacting with the MHC class-Iα chain, these proteins …