The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

Double Holliday junctions (dHJS) are important intermediates of homologous
recombination. The separate junctions can each be cleaved by DNA structure-selective …

The ATR checkpoint kinase coordinates cellular responses to DNA replication stress.
Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only …

The 5′-3′ resection of DNA ends is a prerequisite for the repair of DNA double strand
breaks by homologous recombination, microhomology-mediated end joining, and single …

The RecQ helicases are conserved from bacteria to humans and play a critical role in
genome stability. In humans, loss of RecQ gene function is associated with cancer …

A double Holliday junction (dHJ) is a central intermediate of homologous recombination that
can be processed to yield crossover or non-crossover recombination products. To preserve …

The RecQ family of DNA helicases is highly conserved throughout evolution, and is
important for the maintenance of genome stability. In humans, five RecQ family members …

DNA double-strand breaks (DSBs) in cells can undergo nucleolytic degradation to generate
long 3′ single-stranded DNA tails. This process is termed DNA end resection, and its …

Bloom Syndrome is an autosomal recessive cancer-prone disorder caused by mutations in
the BLM gene. BLM encodes a DNA helicase of the RECQ family, and associates with Topo …

BLM, the helicase mutated in Bloom syndrome, associates with topoisomerase 3α, RMI1
(RecQ-mediated genome instability), and RPA, to form a complex essential for the …