Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disease caused by
deficient activity of acid sphingomyelinase (ASM) enzyme, leading to the accumulation of …

Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially
due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence …

Tumor microenvironment is fundamental for cancer progression and chemoresistance.
Among stromal cells tumor-associated macrophages (TAMs) represent the largest …

Dysregulation of lipid metabolism affects the behavior of cancer cells, but how this happens
is not completely understood. Neutral sphingomyelinase 2 (nSMase2), encoded by SMPD3 …

Mitochondria change distribution across cells following a variety of pathophysiological
stimuli. The mechanisms presiding over this redistribution are yet undefined. In a murine …

Background/Aims: Regulatory T cell (Treg) is required for the maintenance of tolerance to
various tissue antigens and to protect the host from autoimmune disorders. However, Treg …

Several modern drugs, including those for cancer therapy, have been isolated from natural
sources, are based on natural products and its derivatives, or mime natural products. Some …

Climacostol, a compound produced by the ciliated protozoan Climacostomum virens,
displayed cytotoxic properties in vitro. This study demonstrates that it has anti-tumour …

Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its
metastatic potency. Despite remarkable breakthroughs in term of treatments with the …

The sphingolipid metabolising enzyme Acid Sphingomyelinase (A-SMase) has been
recently shown to inhibit melanoma progression and correlate inversely to tumour grade. In …