Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Osteopontin takes center stage in chronic liver disease

Z Song, W Chen, D Athavale, X Ge, R Desert… - …, 2021 - Wiley Online Library
Osteopontin (OPN) was first identified in 1986. The prefix osteo‐means bone; however, OPN
is expressed in other tissues, including liver. The suffix‐pontin means bridge and denotes …

A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs

J Wang, R Ocadiz-Ruiz, MS Hall, GG Bushnell… - Nature …, 2023 - nature.com
Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct
complex signals and facilitate the study of cancer progression and metastasis. Here we …

Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes

L Li, F Fang, X Feng, P Zhuang, H Huang, P Liu, L Liu… - Neuron, 2022 - cell.com
Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …

The significance of SPP1 in lung cancers and its impact as a marker for protumor tumor-associated macrophages

E Matsubara, H Yano, C Pan, Y Komohara, Y Fujiwara… - Cancers, 2023 - mdpi.com
Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …

Osteopontin in cardiovascular diseases

K Shirakawa, M Sano - Biomolecules, 2021 - mdpi.com
Unprecedented advances in secondary prevention have greatly improved the prognosis of
cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally …

T cell immunosenescence in aging, obesity, and cardiovascular disease

K Shirakawa, M Sano - Cells, 2021 - mdpi.com
Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

[HTML][HTML] An all-silk-derived bilayer hydrogel for osteochondral tissue engineering

W Jiang, X Xiang, M Song, J Shen, Z Shi, W Huang… - Materials Today Bio, 2022 - Elsevier
Osteochondral repair remains a challenge in clinical practice nowadays despite extensive
advances in tissue engineering. The insufficient recruitment of endogenous cells in the early …

Progress and prospects of biomarkers in primary liver cancer

YX Gao, TW Yang, JM Yin… - International …, 2020 - spandidos-publications.com
Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation,
recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most …

Examining the function of macrophage oxidative stress response and immune system in glioblastoma multiforme through analysis of single-cell transcriptomics

J Xing, H Cai, Z Lin, L Zhao, H Xu, Y Song… - Frontiers in …, 2024 - frontiersin.org
Background Glioblastoma (GBM), a prevalent malignant neoplasm within the neuro-
oncological domain, has been a subject of considerable scrutiny. Macrophages, serving as …