Osteopontin (OPN) was first identified in 1986. The prefix osteo‐means bone; however, OPN
is expressed in other tissues, including liver. The suffix‐pontin means bridge and denotes …

Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

Although advances in preventive medicine have greatly improved prognosis, cardiovascular
disease (CVD) remains the leading cause of death worldwide. This clearly indicates that …

Simple Summary Macrophages that infiltrate the cancer microenvironment are referred to as
tumor-associated macrophages (TAMs). Phosphoprotein 1 (SPP1), also known as …

Osteochondral repair remains a challenge in clinical practice nowadays despite extensive
advances in tissue engineering. The insufficient recruitment of endogenous cells in the early …

Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …

Tumor biomarkers are important in the early screening, diagnosis, therapeutic evaluation,
recurrence and prognosis prediction of tumors. Primary liver cancer is one of the most …

Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct
complex signals and facilitate the study of cancer progression and metastasis. Here we …

Unprecedented advances in secondary prevention have greatly improved the prognosis of
cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally …

Background Hepatocellular carcinoma (HCC) is one of the most prevalent and inflammation-
associated cancers. The tumor microenvironment (TME) plays an essential role in HCC …