As knowledge of cell metabolism has advanced, glutamine has been considered an
important amino acid that supplies carbon and nitrogen to fuel biosynthesis. A recent study …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and
signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism …

Examining transcriptomic and metabolic responses of earthworms to microplastic-
contaminated soil is critical for understanding molecular-level toxicity of microplastics; yet …

Traditional epitranscriptomics relies on capturing a single RNA modification by antibody or
chemical treatment, combined with short-read sequencing to identify its transcriptomic …

Introduction Microplastic pollution seriously threatens the health and safety of humans and
wildlife. Avian is one of the main species endangered by microplastics. However, the …

Cancer cells exhibit a wide range of metabolic phenotypes, ranging from strict aerobic
glycolysis to increased mitochondrial respiration. The cause and utility of this metabolic …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Non-alcoholic steatohepatitis (NASH) is characterized by the accumulation of hepatic fat in
an inflammatory/fibrotic background. Herein, we show that the hepatic high-activity …