Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors

X Yao, TH Kim - Experimental Biology and Medicine, 2020 - journals.sagepub.com
Quantitative assessment of physiological condition of retinal photoreceptors is desirable for
better detection and treatment evaluation of eye diseases that can cause photoreceptor …

Functional optical coherence tomography of retinal photoreceptors

X Yao, T Son, TH Kim, Y Lu - Experimental Biology and …, 2018 - journals.sagepub.com
Age-related macular degeneration (AMD) is the leading cause of severe vision loss and
legal blindness. It is known that retinal photoreceptors are the primary target of AMD …

Volumetric data analysis enabled spatially resolved optoretinogram to measure the functional signals in the living retina

L Zhang, R Dong, RJ Zawadzki… - Journal of …, 2022 - Wiley Online Library
Optoretinogram, a technique in which optical coherence tomography (OCT) is used to
measure retinal functions in response to a visible light stimulus, can be a potentially useful …

Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

TH Kim, B Wang, Y Lu, T Son, X Yao - Biomedical Optics Express, 2020 - opg.optica.org
Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the
onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a …

Functional optical coherence tomography of neurovascular coupling interactions in the retina

T Son, M Alam, D Toslak, B Wang, Y Lu… - Journal of …, 2018 - Wiley Online Library
Quantitative evaluation of retinal neurovascular coupling is essential for a better
understanding of visual function and early detection of eye diseases. However, there is no …

Functional optical coherence tomography for intrinsic signal optoretinography: recent developments and deployment challenges

TH Kim, G Ma, T Son, X Yao - Frontiers in Medicine, 2022 - frontiersin.org
Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinogram or
optoretinography (ORG), promises a non-invasive method for the objective assessment of …

[HTML][HTML] Light-induced length shrinkage of rod photoreceptor outer segments

Y Lu, J Benedetti, X Yao - Translational Vision Science & …, 2018 - jov.arvojournals.org
Purpose: This study was designed to verify light-induced outer segment (OS) length
shrinkage of rod photoreceptors and to characterize its anatomic source at disc-level …

Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors

Y Lu, B Wang, DR Pepperberg, X Yao - Biomedical optics express, 2016 - opg.optica.org
Transient retinal phototropism (TRP) has been predominantly observed in rod
photoreceptors activated by oblique visible light stimulation. Dynamic confocal microscopy …

In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

B Wang, Y Lu, X Yao - Journal of biomedical optics, 2016 - spiedigitallibrary.org
Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study
and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to …

In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation

Y Lu, C Liu, X Yao - Journal of biomedical optics, 2018 - spiedigitallibrary.org
Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated
retinas, promising a noninvasive biomarker for objective assessment of retinal physiology …