Privileged scaffolds as MAO inhibitors: Retrospect and prospects
This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …
general interest to the medicinal chemistry community because it focuses on the …
MAO enzymes inhibitory activity of new benzimidazole derivatives including hydrazone and propargyl side chains
In the present work, 15 new N'-(arylidene)-4-(1-(prop-2-yn-1-yl)-1H-benzo [d] imidazol-2-yl)
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
benzohydrazide (4a-4o) were designed and synthesized. The structures of the synthesized …
Importance of indazole against neurological disorders
D Pal, P Sahu - Current Topics in Medicinal Chemistry, 2022 - ingentaconnect.com
Indazole is a nitrogen-containing bicyclic compound, having three tautomeric forms:
1Hindazole, 2H-indazole, and 3H-indazole. Mostly, they are considered as 1H-indazole …
1Hindazole, 2H-indazole, and 3H-indazole. Mostly, they are considered as 1H-indazole …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors
In the recent works, it was shown that numerous thiazolylhydrazine derivatives display h
MAO inhibitory activity in the range of micromolar concentration. Hence, in the present study …
MAO inhibitory activity in the range of micromolar concentration. Hence, in the present study …
Synthesis of new hydrazone derivatives for MAO enzymes inhibitory activity
In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized
to evaluate their inhibitory activity against h MAO enzymes. The structures of the newly …
to evaluate their inhibitory activity against h MAO enzymes. The structures of the newly …
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors
Due to their role in the metabolism of monoamine neurotransmitters, MAO-A and MAO-B
present a significant pharmacological interest. For instance the inhibitors of human MAO-B …
present a significant pharmacological interest. For instance the inhibitors of human MAO-B …
Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
In the current work a new class of novel benzothiazole-hydrazone derivatives was designed
and synthesized as h MAO-B inhibitors. Structures of the obtained compounds (3a–3j) were …
and synthesized as h MAO-B inhibitors. Structures of the obtained compounds (3a–3j) were …
Design, Synthesis, and Biological Effect Studies of Novel Benzofuran–Thiazolylhydrazone Derivatives as Monoamine Oxidase Inhibitors
In recent studies, monoamine oxidase (MAO) inhibitory effects of various thiazolylhydrazone
derivatives have been demonstrated. Within the scope of this study, 12 new compounds …
derivatives have been demonstrated. Within the scope of this study, 12 new compounds …