Although chemotherapy can improve the overall survival and prognosis of cancer patients,
chemoresistance remains an obstacle due to the diversity, heterogeneity, and adaptability to …

The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …

The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather
than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its …

A hypoxic microenvironment contributes to tumor progression, with hypoxia-inducible factor-
1α (HIF-1α) being a critical regulator. We have reported that 14-3-3σ is negatively …

Glycolysis contributes to cell metabolism and facilitates cell proliferation of oral squamous
cell carcinoma (OSCC), the most common type of oral cancer. Understanding the regulatory …

Aerobic glycolysis, or the Warburg effect, is regarded as a critical part of metabolic
reprogramming and plays a crucial role in the occurrence and development of tumours …

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3
ubiquitin ligase that has been reported to participate in multiple cellular procedures by …

Background KH-type splicing regulatory protein (KHSRP, also called KSRP), a versatile
RNA-binding protein, plays a critical role in various physiological and pathological …

E3 ubiquitin ligases, an important part of ubiquitin proteasome system, catalyze the covalent
binding of ubiquitin to target substrates, which plays a role in protein ubiquitination and …

Background A number of studies have indicated that Ubiquitin-conjugating enzyme E2T
(UBE2T), as an oncogene, promotes progression and metastasis of lung cancer, including …