The number of druggable tumor-specific molecular aberrations has grown substantially in
the past decade, with a significant survival benefit obtained from biomarker matching …

Many mammalian viruses have properties that can be commandeered for the treatment of
cancer. These characteristics include preferential infection and replication in tumor cells, the …

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma
accounts for the majority of skin cancer–related deaths, but treatment is usually curative …

Background Sentinel-lymph-node biopsy is associated with increased melanoma-specific
survival (ie, survival until death from melanoma) among patients with node-positive …

The incidence of primary cutaneous melanoma has been increasing dramatically for several
decades. Melanoma accounts for the majority of skin cancer–related deaths, but treatment is …

There will be an estimated 6190 new cases of vulvar cancer in 2018, accounting for 0.4% of
all cancers. This is primarily a disease of the elderly with a median age at diagnosis of 68 …

Abstract Background Vulvar melanoma (VuM) and vaginal melanoma (VaM) represent a
unique subgroup of malignant melanomas with important differences in biology and …

This review presents the main challenges encountered when diagnosing unusual variants of
malignant melanoma with the aim of raising awareness to allow application of the most …

Importance In 2015, first-line programmed cell death 1 (PD-1) immune checkpoint inhibitors
(ICI) were Food and Drug Administration (FDA)-approved and National Comprehensive …

Abstract The Ras-Raf-MEK-ERK (Map kinase) cellular pathway is a highly conserved
eukaryotic signaling module that transduces extracellular signals from growth factors and …