Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their
environment with transmembrane chemoreceptor proteins. These receptors operate in …

Many aspects of plant photoperception are mediated by the phytochrome (Phy) family of
bilin-containing photoreceptors that reversibly interconvert between inactive Pr and active …

Histidine kinases (HKs) are major players in bacterial signaling. There has been an
explosion of new HK crystal structures in the last 5 years. We globally analyze the structures …

The agr locus encodes a quorum-sensing (QS) circuit required for the virulence of a
spectrum of Gram-positive pathogens and is, therefore, regarded as an important target for …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Summary Two-component systems (TCSs), which comprise sensor histidine kinases (SHK)
and response-regulator proteins, represent the predominant strategy by which prokaryotes …

In the course of evolution, proteins show a remarkable conservation of their three-
dimensional structure and their biological function, leading to strong evolutionary constraints …

Summary The Gram‐positive bacterium, Staphylococcus aureus, is a versatile pathogen that
can sense and adapt to a wide variety of environments within the human host, in part …