DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological
processes, including gene and transposon silencing, imprinting and X chromosome …

The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …

DNA methylation plays a critical role in the regulation and maintenance of cell-type specific
transcriptional programs. Targeted epigenome editing is an emerging technology to …

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …

DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …

DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …

The Dnmt3a DNA methyltransferase contains in its N-terminal part a PWWP domain that is
involved in chromatin targeting. Here, we have investigated the interaction of the PWWP …

Cell type-specific DNA methylation patterns are established during mammalian
development and maintained in adult somatic cells. Understanding how these patterns of 5 …

In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …