Drugs are a common source of acute kidney injury. Compared with 30 years ago, the
average patient today is older, has more comorbidities, and is exposed to more diagnostic …

Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly
due to the damage or destruction of kidney function by exogenous or endogenous toxicants …

Despite myriad improvements in the care of hospitalized patients, a decline in renal function
remains a common event. Renal function in 4,622 consecutive patients admitted to the …

Prerenal azotemia and acute tubular necrosis, the two forms of ischemic acute renal failure,
account for more than half the cases of renal failure in hospitalized patients. Yet the …

People with type 1 and type 2 diabetes are at risk of developing progressive chronic kidney
disease (CKD) and end-stage kidney failure. Hypertension is a major, reversible risk factor …

Background & Aims Proton pump inhibitors (PPI) have been associated with acute kidney
injury and recent studies suggest that they may be associated with the risk of chronic kidney …

The main mechanisms of nephrotoxicity are vasoconstriction, altered intraglomerular
hemodynamics, tubular cell toxicity, interstitial nephritis, crystal deposition, thrombotic …

Background: Risk factors of drug-induced nephrotoxicity include drug overdose, drug-drug
interactions and drug-related adverse effects. Since the usage of some nephrotoxic drugs is …

Different definitions of acute renal failure (ARF) abound. The existence of multiple definitions
makes it difficult to determine the true epidemiological characteristics of this condition …

Background No tabular summary of potentially life-threatening, kidney-toxic dietary
supplements (DS; includes herbs) based on PubMed case reports is currently available …