Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and cognitive impairment. It is caused by synaptic failure and excessive …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

Neurodegenerative diseases represent a significant unmet medical need in our aging
society. There are no effective treatments for most of these diseases, and we know …

Seizure disorders debilitate more than 65,000,000 people worldwide, with temporal lobe
epilepsy (TLE) being the most common form. Previous studies have shown that …

Mutations in the MECP2 gene underlie a spectrum of neurodevelopmental disorders, most
commonly Rett syndrome (RTT). We ask whether MECP2 mutations interfere with human …

The mechanisms by which prenatal immune activation increase the risk for neuropsychiatric
disorders are unclear. Here, we generated developmental cortical interneurons (cINs) …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

The analysis of animal models of neurological disease has been instrumental in furthering
our understanding of neurodevelopment and brain diseases. However, animal models are …

Summary Gamma-aminobutyric acid (GABA)-releasing interneurons play an important
modulatory role in the cortex and have been implicated in multiple neurological disorders …