The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …

Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …

There is a growing interest in developing microphysiological systems that can be used to
model both normal and pathological human organs in vitro. This “organs-on-chips” …

Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …

The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …

Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …

Over the past six decades the inflation-adjusted cost to bring a new drug to market has been
increasing constantly and doubles every 9 years–now reaching in excess of $2.5 billion …

Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-
approval for clinical use. This failure of the preclinical pipeline highlights the need for …

Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …