Organ-on-a-chip: Recent breakthroughs and future prospects
Q Wu, J Liu, X Wang, L Feng, J Wu, X Zhu… - Biomedical engineering …, 2020 - Springer
The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
physiological organ biomimetic system built on a microfluidic chip. Through a combination of …
Tumor-on-a-chip: from bioinspired design to biomedical application
X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …
cancer biology and develop anticancer therapies. The main challenges in cancer research …
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle
The endocrine system dynamically controls tissue differentiation and homeostasis, but has
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …
not been studied using dynamic tissue culture paradigms. Here we show that a microfluidic …
3D microtumors in vitro supported by perfused vascular networks
There is a growing interest in developing microphysiological systems that can be used to
model both normal and pathological human organs in vitro. This “organs-on-chips” …
model both normal and pathological human organs in vitro. This “organs-on-chips” …
Engineering vascularized organoid-on-a-chip models
VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
The tumor-on-chip: Recent advances in the development of microfluidic systems to recapitulate the physiology of solid tumors
G Trujillo-de Santiago, BG Flores-Garza… - Materials, 2019 - mdpi.com
The ideal in vitro recreation of the micro-tumor niche—although much needed for a better
understanding of cancer etiology and development of better anticancer therapies—is highly …
understanding of cancer etiology and development of better anticancer therapies—is highly …
The relevance and potential roles of microphysiological systems in biology and medicine
JP Wikswo - Experimental biology and medicine, 2014 - journals.sagepub.com
Microphysiological systems (MPS), consisting of interacting organs-on-chips or tissue-
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …
engineered, 3D organ constructs that use human cells, present an opportunity to bring new …
Applications of tumor chip technology
SJ Hachey, CCW Hughes - Lab on a Chip, 2018 - pubs.rsc.org
Over the past six decades the inflation-adjusted cost to bring a new drug to market has been
increasing constantly and doubles every 9 years–now reaching in excess of $2.5 billion …
increasing constantly and doubles every 9 years–now reaching in excess of $2.5 billion …
An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy
SJ Hachey, S Movsesyan, QH Nguyen, G Burton-Sojo… - Lab on a Chip, 2021 - pubs.rsc.org
Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-
approval for clinical use. This failure of the preclinical pipeline highlights the need for …
approval for clinical use. This failure of the preclinical pipeline highlights the need for …
Liver microphysiological systems for predicting and evaluating drug effects
AJS Ribeiro, X Yang, V Patel… - Clinical …, 2019 - Wiley Online Library
Liver plays a major role in drug metabolism and is one of the main sites of drug adverse
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …
effects. Microphysiological systems (MPS), also known as organs‐on‐a‐chip, are a class of …