Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

Infections caused by resistant bacteria are nowadays too common, and some pathogens
have even become resistant to multiple types of antibiotics, in which case few or even no …

The worldwide emergence of New Delhi metallo-β-lactamase-1 (NDM-1) as a
carbapenemase able to hydrolyze nearly all available β-lactam antibiotics has characterized …

Antibiotic resistance caused by β-lactamase production continues to present a growing
challenge to the efficacy of β-lactams and their role as the most important class of clinically …

The β-lactams are the most successful class of antibiotic drugs but they are vulnerable to
inactivation by a growing cadre of β-lactamases that now number more than a thousand …

The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

Resistance to β‐lactam antibacterials is commonly associated with the production of the
serine β‐lactamases (SBLs) and/or metallo‐β‐lactamases (MBLs). Although clinically useful …

Class B metallo-β-lactamases (MBLs) are Zn 2+-dependent enzymes that catalyze the
hydrolysis of β-lactam antibiotics to confer resistance in bacteria. Several problematic …