State-of-the-art of profiling immune contexture in the era of multiplexed staining and digital analysis to study paraffin tumor tissues

ER Parra, A Francisco-Cruz, II Wistuba - Cancers, 2019 - mdpi.com
Multiplexed platforms for multiple epitope detection have emerged in the last years as very
powerful tools to study tumor tissues. These revolutionary technologies provide important …

MALDI mass spectrometry imaging: A cutting‐edge tool for fundamental and clinical histopathology

R Longuespée, R Casadonte… - PROTEOMICS …, 2016 - Wiley Online Library
Histopathological diagnoses have been done in the last century based on hematoxylin and
eosin staining. These methods were complemented by histochemistry, electron microscopy …

Rapid MALDI mass spectrometry imaging for surgical pathology

SS Basu, MS Regan, EC Randall… - NPJ precision …, 2019 - nature.com
Matrix assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) is an
emerging analytical technique, which generates spatially resolved proteomic and …

Charge distribution between different classes of glycerophospolipids in MALDI-MS imaging

MS Boskamp, J Soltwisch - Analytical chemistry, 2020 - ACS Publications
Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is
widely used to visualize and analyze the distribution of membrane lipids in an increasingly …

Recognition and avoidance OF ION source‐generated artifacts IN lipidomics analysis

C Hu, W Luo, J Xu, X Han - Mass spectrometry reviews, 2022 - Wiley Online Library
Lipid research is attracting more and more attention as various key roles and novel
biological functions of lipids have been demonstrated and discovered in the organism. Mass …

Trends in mass spectrometry imaging for cardiovascular diseases

STP Mezger, AMA Mingels, O Bekers… - Analytical and …, 2019 - Springer
Mass spectrometry imaging (MSI) is a widely established technology; however, in the
cardiovascular research field, its use is still emerging. The technique has the advantage of …

Seeing is Believing: Developing Multimodal Metabolic Insights at the Molecular Level

RS Chadha, JA Guerrero, L Wei… - ACS Central Science, 2024 - ACS Publications
This outlook explores how two different molecular imaging approaches might be combined
to gain insight into dynamic, subcellular metabolic processes. Specifically, we discuss how …

Enterohemorrhagic Escherichia coli and a Fresh View on Shiga Toxin-Binding Glycosphingolipids of Primary Human Kidney and Colon Epithelial Cells and Their …

J Detzner, G Pohlentz, J Müthing - International Journal of Molecular …, 2022 - mdpi.com
Enterohemorrhagic Escherichia coli (EHEC) are the human pathogenic subset of Shiga
toxin (Stx)-producing E. coli (STEC). EHEC are responsible for severe colon infections …

Shiga toxin-glycosphingolipid interaction: Status quo of research with focus on primary human brain and kidney endothelial cells

N Legros, G Pohlentz, D Steil, J Müthing - International Journal of Medical …, 2018 - Elsevier
Shiga toxin (Stx)-mediated injury of the kidneys and the brain represent the major
extraintestinal complications in humans upon infection by enterohemorrhagic Escherichia …

Direct visualization of neurotransmitters in rat brain slices by desorption electrospray ionization mass spectrometry imaging (DESI-MS)

AMAP Fernandes, PH Vendramini… - Journal of The …, 2016 - ACS Publications
Mass spectrometry imaging (MSI) of neurotransmitters has so far been mainly performed by
matrix-assisted laser desorption/ionization (MALDI) where derivatization reagents …