The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …

Abnormal metabolism is common in cancer cells and often correlates with mutations in
genes encoding for enzymes involved in small-molecule metabolism. Isocitrate …

The intestinal microbiota is associated with the development of benzene-induced
hematopoietic toxicity. Modulation of intestinal homeostasis by probiotic supplementation …

Triple-negative breast cancer (TNBC) is traditionally considered a glycolytic tumor with a
poor prognosis while lacking targeted therapies. Here we show that high expression of …

Recent advance in cancer research sheds light on the contribution of mitochondrial
respiration in tumorigenesis, as they efficiently produce ATP and oncogenic metabolites that …

High-risk neuroblastoma remains therapeutically challenging to treat, and the mechanisms
promoting disease aggression are poorly understood. Here, we show that elevated …

Abstract Objective Immature CD11b+ Gr1+ myeloid cells that acquire immunosuppressive
capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous …

The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and
precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations …

Tricarboxylic acid (TCA) cycle, also called Krebs cycle or citric acid cycle, is an amphoteric
pathway, contributing to catabolic degradation and anaplerotic reactions to supply …

Rationale: Adenylosuccinate lyase (ADSL) is an essential enzyme for de novo purine
biosynthesis. Here we sought to investigate the putative role of ADSL in colorectal …