Dissecting metastasis using preclinical models and methods
JD Hebert, JW Neal, MM Winslow - Nature Reviews Cancer, 2023 - nature.com
Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …
deaths. However, our understanding of the metastatic process, and thus our ability to …
Mouse models for human lung cancer
R Meuwissen, A Berns - Genes & development, 2005 - genesdev.cshlp.org
In recent years several new mouse models for lung cancer have been described. These
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …
include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer …
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of
advanced cancer, but its biological basis has remained obscure. We demonstrate here a …
advanced cancer, but its biological basis has remained obscure. We demonstrate here a …
UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis
Cancer metastasis is the primary cause of morbidity and mortality, and accounts for up to
95% of cancer-related deaths. Cancer cells often reprogram their metabolism to efficiently …
95% of cancer-related deaths. Cancer cells often reprogram their metabolism to efficiently …
Tumour angiogenesis regulation by the miR-200 family
The miR-200 family is well known to inhibit the epithelial–mesenchymal transition,
suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports …
suggesting it may therapeutically inhibit metastatic biology. However, conflicting reports …
Mediating passive tumor accumulation through particle size, tumor type, and location
As the enhanced permeation and retention (EPR) effect continues to be a controversial topic
in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor …
in nanomedicine, we sought to examine EPR as a function of nanoparticle size, tumor …
The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer
Programmed cell death ligand-1 (PD-L1) has recently gained considerable attention for its
role in tumor immune escape. Here, we identify a miR-197/CKS1B/STAT3-mediated PD-L1 …
role in tumor immune escape. Here, we identify a miR-197/CKS1B/STAT3-mediated PD-L1 …
H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM
G9a is a mammalian histone methyltransferase that contributes to the epigenetic silencing of
tumor suppressor genes. Emerging evidence suggests that G9a is required to maintain the …
tumor suppressor genes. Emerging evidence suggests that G9a is required to maintain the …
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non–small cell lung cancer
PC Ma, R Jagadeeswaran, S Jagadeesh… - Cancer research, 2005 - AACR
Non–small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an
attractive potential target for novel therapeutic inhibition in human cancers. We provide …
attractive potential target for novel therapeutic inhibition in human cancers. We provide …
Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology
Generation of genetically engineered mouse models (GEMMs) for chromosomal
translocations in the endogenous loci by a knockin strategy is lengthy and costly. The …
translocations in the endogenous loci by a knockin strategy is lengthy and costly. The …