[HTML][HTML] Advancing cell-based cancer immunotherapy through stem cell engineering
Advances in cell-based therapy, particularly CAR-T cell therapy, have transformed the
treatment of hematological malignancies. Although an important step forward for the field …
treatment of hematological malignancies. Although an important step forward for the field …
Past, present, and future of CRISPR genome editing technologies
Genome editing has been a transformative force in the life sciences and human medicine,
offering unprecedented opportunities to dissect complex biological processes and treat the …
offering unprecedented opportunities to dissect complex biological processes and treat the …
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours
Adoptive T-cell therapy against solid tumours is limited by the apoptosis resistance
mechanisms of tumour cells and by the extracellular, immunosuppressive tumour …
mechanisms of tumour cells and by the extracellular, immunosuppressive tumour …
Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti–PD-1 immunotherapy
The tumor-intrinsic NOD-, LRR-and pyrin domain-containing protein-3 (NLRP3)
inflammasome–heat shock protein 70 (HSP70) signaling axis is triggered by CD8+ T cell …
inflammasome–heat shock protein 70 (HSP70) signaling axis is triggered by CD8+ T cell …
[HTML][HTML] Roles of glycosylation at the cancer cell surface: opportunities for large scale glycoproteomics
Cell surface glycosylation has a variety of functions, and its dysregulation in cancer
contributes to impaired signaling, metastasis and the evasion of the immune responses …
contributes to impaired signaling, metastasis and the evasion of the immune responses …
Aneuploidy in human cancer: new tools and perspectives
Chromosome copy number imbalances, otherwise known as aneuploidies, are a common
but poorly understood feature of cancer. Here, we describe recent advances in both …
but poorly understood feature of cancer. Here, we describe recent advances in both …
[HTML][HTML] CRISPR/Cas9-Mediated Genome Editing in Cancer Therapy
The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …
[HTML][HTML] Comprehensive epigenomic profiling reveals the extent of disease-specific chromatin states and informs target discovery in ankylosing spondylitis
AC Brown, CJ Cohen, O Mielczarek, G Migliorini… - Cell Genomics, 2023 - cell.com
Ankylosing spondylitis (AS) is a common, highly heritable inflammatory arthritis
characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association …
characterized by enthesitis of the spine and sacroiliac joints. Genome-wide association …
[HTML][HTML] A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity
D Lee, H Ahn, HI Sim, E Choi, S Choi, Y Jo… - Journal of Experimental …, 2023 - Springer
Background Immunotherapy has significantly advanced cancer treatments, but many
patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor …
patients do not respond to it, partly due to immunosuppressive mechanisms used by tumor …
[HTML][HTML] Functional CRISPR screens in T cells reveal new opportunities for cancer immunotherapies
M Xiang, H Li, Y Zhan, D Ma, Q Gao, Y Fang - Molecular Cancer, 2024 - Springer
T cells are fundamental components in tumour immunity and cancer immunotherapies,
which have made immense strides and revolutionized cancer treatment paradigm. However …
which have made immense strides and revolutionized cancer treatment paradigm. However …