From compulsivity to compulsion: the neural basis of compulsive disorders
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
potential transdiagnostic symptom of several neuropsychiatric disorders, including …
Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model
BJG van den Boom, A Elhazaz-Fernandez… - Nature …, 2023 - nature.com
Deep-brain stimulation (DBS) is an effective treatment for patients suffering from otherwise
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …
therapy-resistant psychiatric disorders, including obsessive-compulsive disorder …
Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies
MPN Perera, ES Gotsis, NW Bailey… - Cerebral …, 2024 - academic.oup.com
Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition that is difficult to
treat due to our limited understanding of its pathophysiology. Functional connectivity in brain …
treat due to our limited understanding of its pathophysiology. Functional connectivity in brain …
Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial
New interventions are needed for obsessive-compulsive disorder. Here we present a
randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing …
randomized single-blinded, two-arm, parallel-group, sham-controlled clinical trial assessing …
Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults
Successful explicit memory encoding is associated with inferior temporal activations and
medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal …
medial parietal deactivations, which are attenuated in aging. Here we used dynamic causal …
Multiscale heterogeneity of white matter morphometry in psychiatric disorders
Background. Inter-individual variability in neurobiological and clinical characteristics in
mental illness is often overlooked by classical group-mean case-control studies. Studies …
mental illness is often overlooked by classical group-mean case-control studies. Studies …
Deep Brain Stimulation of the Nucleus Accumbens for Severe Self-Injurious Behaviour in Children: A Phase I Pilot Trial
C Gorodetsky, K Mithani, S Breitbart, H Yan, K Zhang… - Biological …, 2024 - Elsevier
Background Self-injurious behaviours (SIB) are repetitive, non-accidental movements that
result in physical damage inflicted upon oneself, without suicidal intent. SIB are prevalent …
result in physical damage inflicted upon oneself, without suicidal intent. SIB are prevalent …
Distinct cognitive and functional connectivity features from healthy cohorts inform clinical obsessive-compulsive disorder
Improving diagnostic accuracy of obsessive-compulsive disorder (OCD) using models of
brain imaging data is a key goal of the field, but this objective is challenging due to the …
brain imaging data is a key goal of the field, but this objective is challenging due to the …
Limited evidence of deficits in threat and safety signal neural processing in obsessive-compulsive disorder
Background Current behavioural treatment of obsessive-compulsive disorder (OCD) is
informed by fear conditioning and involves iteratively re-evaluating previously threatening …
informed by fear conditioning and involves iteratively re-evaluating previously threatening …
Distinct cognitive and functional connectivity features from healthy cohorts can identify clinical obsessive-compulsive disorder
Improving diagnostic accuracy of obsessive-compulsive disorder (OCD) using models of
brain imaging data is a key goal of the field, but this objective is challenging due to the …
brain imaging data is a key goal of the field, but this objective is challenging due to the …