Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …

Tumor development and progression require chemical and mechanical cues derived from
cellular and non-cellular components in the tumor microenvironment, including the …

Blood vessels supply all body tissues with nutrients and oxygen, take away waste products
and allow the arrival of immune cells and other cells (pericytes, smooth muscle cells) that …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer,
has a median overall survival of 6–12 months and a 5-year survival of less than 7%. While …

Pancreatic ductal adenocarcinoma (PDAC) has one of the worst outcomes among cancers
with a 5-years survival rate of below 10%. This is a result of late diagnosis and the lack of …

Vasculogenic mimicry (VM) is a vascular formation mechanism used by aggressive tumor
cells. VM provides an alternative pathway for adequate blood perfusion and challenges the …

Muscular diseases and injuries are challenging issues in human medicine, resulting in
physical disability. The advent of tissue engineering approaches has paved the way for the …

Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Cancer is a major problem in the health system, and despite many efforts to effectively treat
it, none has yet been fully successful. Angiogenesis and metastasis are considered as major …