The concerted interaction of genetic and environmental factors acts on the preterm human
immature lung with inflammation being the common denominator leading to the …

Alveolarization is the process by which the alveoli, the principal gas exchange units of the
lung, are formed. Along with the maturation of the pulmonary vasculature, alveolarization is …

MV is undoubtedly one of the key advances in neonatal care. Even in this era of noninvasive
respiratory support, MV remains a mainstay of therapy in the extremely preterm population …

BACKGROUND: Studies suggest that giving newly born preterm infants sustained lung
inflation (SLI) may decrease their need for mechanical ventilation (MV) and improve their …

Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, with
appreciable morbidity and mortality in a neonatal intensive care setting. Much interest has …

Rationale: The preterm lung is susceptible to injury during transition to air breathing at birth.
It remains unclear whether rapid or gradual lung aeration at birth causes less lung injury …

A necessidade de intubação e do uso de ventilação mecânica na prematuridade está
relacionada à chamada lesão pulmonar induzida pela ventilação e à consequente displasia …

This paper is focused on unique insights provided by the preterm lamb physiological model
of bronchopulmonary dysplasia (BPD). Connections are also made to insights provided by …

Rationale: Inflation is essential for aeration at birth, but current inflating pressure settings are
without an evidence base. Objectives: To determine the role of inflating pressure (ΔP), and …

Tidal ventilation is essential in supporting the transition to air-breathing at birth, but
excessive tidal volume (VT) is an important factor in preterm lung injury. Few studies have …