Advancement in leishmaniasis diagnosis and therapeutics: An update

D Kumari, S Perveen, R Sharma, K Singh - European Journal of …, 2021 - Elsevier
Leishmaniasis is regarded as a neglected tropical disease by World Health Organization
(WHO) and is ranked next to malaria as the deadliest protozoan disease. The primary …

Host-directed drug therapies for neglected tropical diseases caused by protozoan parasites

S Varikuti, BK Jha, G Volpedo, NM Ryan… - Frontiers in …, 2018 - frontiersin.org
The neglected tropical diseases (NTDs) caused by protozoan parasites are responsible for
significant morbidity and mortality worldwide. Current treatments using anti-parasitic drugs …

An appraisal of the scientific current situation and new perspectives in the treatment of cutaneous leishmaniasis

CAB Nieva, AG Cid, AI Romero, MF García-Bustos… - Acta Tropica, 2021 - Elsevier
Abstract Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of
the genus Leishmania. It is a major health problem in many tropical and subtropical regions …

Cutaneous/mucocutaneous leishmaniasis treatment for wound healing: classical versus new treatment approaches

P Severino, W Santana, ES Lisboa, VLS Santos… - Microbiology …, 2022 - mdpi.com
Cutaneous leishmaniasis (CL) and mucocutaneous leishmaniasis (ML) show clinical
spectra that can range from a localized lesion (with a spontaneous healing process) to …

[HTML][HTML] Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents

B Mendes, JR Almeida, N Vale, P Gomes… - … and Physiology Part C …, 2019 - Elsevier
Phospholipase A 2 toxins present in snake venoms interact with biological membranes and
serve as structural models for the design of small peptides with anticancer, antibacterial and …

Neglected zoonotic diseases: Advances in the development of cell-penetrating and antimicrobial peptides against leishmaniosis and Chagas disease

SM Robledo, S Pérez-Silanes, C Fernández-Rubio… - Pathogens, 2023 - mdpi.com
In 2020, the WHO established the road map for neglected tropical diseases 2021–2030,
which aims to control and eradicate 20 diseases, including leishmaniosis and Chagas …

Host-directed therapies for parasitic diseases

B Singh, S Varikuti, G Halsey, G Volpedo… - Future medicinal …, 2019 - Taylor & Francis
Parasitic infections are responsible for significant morbidity and mortality throughout the
world. Management strategies rely primarily on antiparasitic drugs that have side effects and …

Panacea within a Pandora's box: the antiparasitic effects of phospholipases A2 (PLA2s) from snake venoms

SC Teixeira, MS da Silva, AAS Gomes, NS Moretti… - Trends in …, 2022 - cell.com
Parasitic diseases affect millions of individuals worldwide, mainly in low-income regions.
There is no cure for most of these diseases, and the treatment relies on drugs that have side …

Nanotechnology as an alternative to improve the treatment of cutaneous leishmaniasis: A systematic review of the literature

ES De Santana, VB de Souza Belmiro… - Journal of Drug Delivery …, 2022 - Elsevier
Cutaneous leishmaniasis (CL) is a neglected infectious disease caused by the Leishmania
spp parasite and transmitted through the bite of sandflies. Humans are infected by the …

A natural cell-penetrating nanopeptide combined with pentavalent antimonial as experimental therapy against cutaneous leishmaniasis

JRV Silva, NB de Barros, SRA Macedo… - Experimental …, 2020 - Elsevier
The inadequacy of available treatments for leishmaniasis has presented up to 40%
therapeutic failure. This fact suggests an urgency in the discovery of new drugs or alternative …