The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …

The BAFF-receptor (BAFFR) is encoded by the TNFRSF13C gene and is one of the main pro-
survival receptors in B cells. Its function is impressively documented in humans by a …

Systemic lupus erythematosus (SLE) is characterized by multisystem immune-mediated
injury in the setting of autoimmunity to nuclear antigens. The clinical heterogeneity of SLE …

The BAFF system plays a key role in the development of autoimmunity, especially in
systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly …

BAFF, APRIL and their receptors play important immunological roles, especially in the B cell
arm of the immune system. A number of splice isoforms have been described for both …

Despite the growing number of examples of small-molecule inhibitors that disrupt protein–
protein interactions (PPIs), the origin of druggability of such targets is poorly understood. To …

The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas
APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF …

B cells have an ever-increasing role in the etiopathology of a number of autoimmune
neurological disorders, acting as antigen-presenting cells facilitating antibody production but …

Cytokines mediate key communication pathways essential for regulation of immune
responses. Full activation of antigen‐responding lymphocytes requires cooperating signals …

B cells play a pivotal role in the pathogenesis of autoimmune disease (AD) by the production
of autoantibodies, secretion of cytokines and presentation of autoantigens. As a pro-survival …