Fluorescent probes are one of the cornerstones of real-time imaging of live cells and a
powerful tool for cell biologists. They provide high sensitivity and great versatility while …

Protein interactions are a fundamental mechanism for the generation of biological regulatory
specificity. The study of protein interactions in living cells is of particular significance …

Proteins provide the building blocks for multicomponent molecular units, or pathways, from
which higher cellular functions emerge. These units consist of either assemblies of …

Mitochondrial movement and distribution are fundamental to their function. Here we report a
mechanism that regulates mitochondrial movement by anchoring mitochondria to the F-actin …

Numerous cellular processes require the concerted action of multiple proteins that assemble
in functional complexes. Protein-protein interaction domains allow specific proteins to …

During sarcomere contraction skeletal and cardiac muscle cells consume large amounts of
energy. To satisfy this demand, metabolic enzymes are associated with distinct regions of …

GTPases of the Rho family are transducers of extracellular signals and control cellular
processes such as organization of the actin cytoskeleton, motility, adhesion and gene …

A variety of experimental methods have been developed for the analysis of protein
interactions. The majority of these methods either require disruption of the cells to detect …

We describe the development of a microfluidic platform for continuous monitoring of gene
expression in live cells. This optically transparent microfluidic device integrates high …

Recent studies using insulin-like growth factor I (IGF-I) knockout mice demonstrate that IGF-
binding protein (IGFBP)-5, an important bone formation regulator, itself is a growth factor …