Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Alzheimer's disease (AD), a common neurodegenerative disease in the elderly and the most
prevalent cause of dementia, is characterized by progressive cognitive impairment. The …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disease. Despite
tremendous research efforts to understand this complex disease, the exact pathophysiology …

The autophagy–lysosomal pathway plays a critical role in intracellular clearance and
metabolic homeostasis. While neuronal autophagy is known to participate in the …

Among the main bacteria implicated in the pathology of periodontal disease,
Aggregatibacter actinomycetemcomitans (Aa) is well known for causing loss of periodontal …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Fungal airway infection (airway mycosis) is an important cause of allergic airway diseases
such as asthma, but the mechanisms by which fungi trigger asthmatic reactions are poorly …

The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …

Alzheimer disease (AD) is the most prominent form of dementia and the 5th leading cause of
death in individuals over 65. AD is a complex disease stemming from genetic …

More than 300 years ago, Antony van Leewenhoeck first described observing single-celled
microorganisms, which he termed “animalcules,” examining his saliva under a microscope …