Autophagy and inflammation in chronic respiratory disease
AC Racanelli, SA Kikkers, AMK Choi, SM Cloonan - Autophagy, 2018 - Taylor & Francis
Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …
Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology
Cystic Fibrosis (CF) is a genetic disorder that arises due to mutations in the Cystic Fibrosis
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …
Transmembrane Conductance Regulator gene, which encodes for a protein responsible for …
Recent advances in our understanding of the mechanisms of lung alveolarization and bronchopulmonary dysplasia
E Lignelli, F Palumbo, D Myti… - American Journal of …, 2019 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is the most common cause of morbidity and mortality in
preterm infants. A key histopathological feature of BPD is stunted late lung development …
preterm infants. A key histopathological feature of BPD is stunted late lung development …
The prophylaxis and treatment potential of supplements for COVID-19
The global impact of the new coronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months …
(SARS-CoV-2), infection that caused COVID-19 has been evident in the last few months …
Role of autophagy in lung diseases and ageing
Y Zhang, J Zhang, Z Fu - European Respiratory Review, 2022 - Eur Respiratory Soc
The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic
stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a …
stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a …
The role of zinc in the pathogenesis of lung disease
Lung diseases, such as asthma, chronic obstructive pulmonary diseases (COPD), and cystic
fibrosis (CF), are among the leading causes of mortality and morbidity globally. They …
fibrosis (CF), are among the leading causes of mortality and morbidity globally. They …
[HTML][HTML] TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway
Thymic stromal lymphopoietin (TSLP) is a cytokine mainly released by epithelial cells that
plays important roles in inflammation, autoimmune disease, and cancer. While TSLP is …
plays important roles in inflammation, autoimmune disease, and cancer. While TSLP is …
Zinc deficiency as a codeterminant for airway epithelial barrier dysfunction in an ex vivo model of COPD
E Roscioli, HPA Jersmann, S Lester… - … journal of chronic …, 2017 - Taylor & Francis
There is now convincing evidence that the airway epithelium drives the pathogenesis of
COPD. A major aspect of this is the disease-related reduction in barrier function that is …
COPD. A major aspect of this is the disease-related reduction in barrier function that is …
Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis
M Bodas, G Pehote, D Silverberg, E Gulbins… - Free Radical Biology and …, 2019 - Elsevier
In this study, we aimed to investigate precise mechanism (s) of sphingolipid-imbalance and
resulting ceramide-accumulation in COPD-emphysema. Where, human and murine …
resulting ceramide-accumulation in COPD-emphysema. Where, human and murine …
Airway epithelial cells exposed to wildfire smoke extract exhibit dysregulated autophagy and barrier dysfunction consistent with COPD
Background Individuals with respiratory disease are being increasingly exposed to wildfire
smoke as populations encroach further into forested regions and climate change continues …
smoke as populations encroach further into forested regions and climate change continues …