Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

The brain is astonishing in its complexity and capacity for change. This has fascinated
scientists for more than a century, filling the pages of this journal for the past 25 years. But a …

The eukaryotic family of RNA-binding proteins termed PUF (Pumilio and FBF) is known for
its roles in cell division, differentiation and development. The best-characterized function of …

Genome-wide identification of mRNAs regulated by RNA-binding proteins is crucial to
uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA …

Throughout life, neural circuits change their connectivity, especially during development,
when neurons frequently extend and retract dendrites and axons, and form and eliminate …

Puf proteins are regulators of diverse eukaryotic processes including stem cell maintenance,
organelle biogenesis, oogenesis, neuron function, and memory formation. At the molecular …

Post-transcriptional regulation of gene expression plays a crucial role in many processes. In
cells, it is mediated by diverse RNA-binding proteins. These proteins can influence mRNA …

Localization of an mRNA species to a particular subcellular region can complement
translational control mechanisms to produce a restricted spatial distribution of the protein it …

Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the
Pumilio (Pum) and Nanos (Nos) translational repressors. Upon division, Dpp signaling is …

TRIM-NHL proteins are conserved regulators of development and differentiation but their
molecular function has remained largely elusive. Here, we report an as yet unrecognized …