Scientists have known for many years that the expression of a euka ryotic gene can be
affected by its chromosomal position (see Sturtevant 1925; Dobzhansky 1936; Lewis 1950) …

The ability to introduce foreign genes into the germ line and the successful expression of the
inserted gene in the organism have allowed the genetic manipulation of animals on an …

The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the
interferon-induced antiviral response. In this study, we report that interferon-α (IFN-α) …

Glucokinase (GK) gene mutations cause diabetes mellitus in both humans and mouse
models, but the pathophysiological basis is only partially defined. We have used cre …

The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …

The variability in the prognosis of individuals with hepatocellular carcinoma (HCC) suggests
that HCC may comprise several distinct biological phenotypes. These phenotypes may …

We have constructed a “minilocus” that contains the 5'and 3'flanking regions of the human P-
globin locus and the B-globin gene. These regions are characterized by erythroid-specific …

A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10
homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine …

We have studied the initial development of pluripotent gut endoderm to hepatocytes using a
tissue explant system from mouse embryos. We not only find cellular interactions that specify …

Specific cell ablation is a useful method for analyzing the in vivo function of cells. We have
developed a simple and sensitive method for conditional cell ablation in transgenic mice …